Conclusion: Over - expression of Smad 7 may contribute to formation of aberrant hyperplastic epidermis in seborrheic keratosis.

结论: 脂溢性角化病皮损表皮中Smad7过度表达可能有助于表皮细胞的异常增生,促进脂溢性角化病的形成.

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C - ski is transcriptional co - repressors that inhibit transforming growth factor - beta ( TGF - beta ) signaling through interaction with Smad 3, Smad 2 protein.

同时,近些年研究表明TGF -beta 信号系统是导致瘢痕形成的重要原因,而Smad3和Smad2做为TGF -beta 途径重要的信号因子,在瘢痕形成中具有重要作用, 因此,抑制Smad3和Smad2成为了减轻瘢痕形成的新途径.

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