RESULTS: Aristolochic acid has nephrotoxicity, alimentary canal toxicity, carcinogenicity, mutagenicity and genotoxicity.

结果: 马兜铃酸具有肾毒性 、 消化道毒性 、 致癌性 、 致突变性和基因毒性.

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To establish a limiting detection for aristolochic acid A in Xiaoqinglong mixture.

目的:建立小青龙合剂中马兜铃酸A的限量检查方法.

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Objective To control the quantity of aristolochic acid in Xinmazhike Granules.

目的控制辛麻止咳颗粒中马兜铃酸的含量.

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Conclusion There is no aristolochic acid in Xinmazhike Granules.

结论该品中不含马兜铃酸.

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CONCLUSION: We should dialectically and rationally use Chinese crude drug containing the component of aristolochic acid.

结论: 要辨证合理使用含有马兜铃酸成分的中药材.

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METHODS: We analyzed the causes accountable for the renal toxicity of Aristolochic acid - containing Chinese medicines.

方法:分 析含马兜铃酸类中药引起马兜铃酸肾毒性的原因.

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Objective To research the content changes of Aristolochic Acid - A from Aristolochiae Manshuriensis and its processed products.

目的考察关木通药材及其炮制品中马兜铃酸A的含量变化.

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Method Searching published literatures and website associated with aristolochic acid toxicities and abroad and analyzing them.

方法通过检索国内外公开发表的文献和各国官方网站,收集与马兜铃酸有关的不良反应病例,分析其安全性.

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Methods HPLC was used to determine the content of aristolochic acid in Xinmazhike Granules.

方法采用高效液相色谱法建立了辛麻止咳颗粒中马兜铃酸的含量测定方法.

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